Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides

Six tripeptides incorporating acidic amino acid residues were prepared for investigation as activators of β- and γ-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacteria Vibrio cholerae, Mycobacterium tuberculosis, and Burkholderia pseudomallei. The primary amino acid residues that are i...

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Detalhes bibliográficos
Main Authors: Azzurra Stefanucci, Andrea Angeli, Marilisa Pia Dimmito, Grazia Luisi, Sonia Del Prete, Clemente Capasso, William A. Donald, Adriano Mollica, Claudiu T. Supuran
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2018-01-01
Colecção:Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:
Carbonic anhydrase
tripeptide
activator
proton transfer
pathogenic bacteria
Acesso em linha:http://dx.doi.org/10.1080/14756366.2018.1468530
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