RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection

Abstract Background Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. Cigarette smoke (CS) exposure increases the frequency and severity of respiratory tract inf...

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Hauptverfasser: Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J. Leland Booth, Elizabeth S. Duggan, Lili Tian, Sunil More, Yan D. Zhao, Ravindranauth N. Sawh, Lin Liu, Ming-Hui Zou, Jordan P. Metcalf
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-09-01
Schriftenreihe:Respiratory Research
Schlagworte:
Influenza virus
Lung
Smoking
Cytokine
RIG-I
Transgenic mouse
Online Zugang:http://link.springer.com/article/10.1186/s12931-017-0649-z
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