Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.

In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into the structure and function of bivalent domains, we...

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Hlavní autoři: Manching Ku, Richard P Koche, Esther Rheinbay, Eric M Mendenhall, Mitsuhiro Endoh, Tarjei S Mikkelsen, Aviva Presser, Chad Nusbaum, Xiaohui Xie, Andrew S Chi, Mazhar Adli, Simon Kasif, Leon M Ptaszek, Chad A Cowan, Eric S Lander, Haruhiko Koseki, Bradley E Bernstein
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2008-10-01
Edice:PLoS Genetics
On-line přístup:http://europepmc.org/articles/PMC2567431?pdf=render
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