Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

We report the application of single molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over 4 billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin state maps of mouse embryonic st...

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Autori principali: Mikkelsen, Tarjei S., Ku, Manching, Jaffe, David B., Issac, Biju, Lieberman, Erez, Giannoukos, Georgia, Alvarez, Pablo, Brockman, William, Kim, Tae-Kyung, Koche, Richard P., Lee, William, Mendenhall, Eric, O’Donovan, Aisling, Presser, Aviva, Russ, Carsten, Xie, Xiaohui, Meissner, Alexander, Wernig, Marius, Jaenisch, Rudolf, Nusbaum, Chad, Lander, Eric S., Bernstein, Bradley E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921165/
https://ncbi.nlm.nih.gov/pubmed/17603471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06008
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