Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue

Each heartbeat is initiated by specialized pacemaker cells operating within the sinoatrial node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of their electrophysiological parameters and Ca cycling, the role of this heterogeneity for cardiac pacemaker function rem...

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Hauptverfasser: Alexander V. Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-04-01
Schriftenreihe:Frontiers in Physiology
Schlagworte:
sinoatrial node
coupled-clock pacemaker system
numerical modeling
calcium release
sarcoplasmic reticulum
cardiac arrhythmia
Online Zugang:https://www.frontiersin.org/articles/10.3389/fphys.2022.845634/full
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