Development and Differentiation in Monobodies Based on the Fibronectin Type 3 Domain

As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain overcome antibody size and complexity while maintaining analogous binding loops. However, antibodies and their derivatives remain the gold standard for the design of new therapeutics. In response, clinical-stage th...

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Dettagli Bibliografici
Autori principali: Peter G. Chandler, Ashley M. Buckle
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-03-01
Serie:Cells
Soggetti:
adnectin
biosensor
fibronectin
monobody
non-antibody scaffold
therapeutic
Accesso online:https://www.mdpi.com/2073-4409/9/3/610
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