Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain

Consensus protein design is a rapid and reliable technique for the improvement of protein stability, which relies on the use of homologous protein sequences. To enhance the stability of a fibronectin type III (FN3) domain, consensus design was employed using an alignment of 2123 sequences. The resul...

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Publicat a:Protein Eng Des Sel
Autors principals: Porebski, Benjamin T., Nickson, Adrian A., Hoke, David E., Hunter, Morag R., Zhu, Liguang, McGowan, Sheena, Webb, Geoffrey I., Buckle, Ashley M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330816/
https://ncbi.nlm.nih.gov/pubmed/25691761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv002
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