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p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions
Abstract Background As an important cellular stress sensor phosphoprotein p53 can trigger cell cycle arrest and apoptosis and regulate autophagy. The p53 activity mainly depends on its transactivating function, however, how p53 can select one or another biological outcome is still a matter of profou...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2017-09-01
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| Colecção: | Journal of Experimental & Clinical Cancer Research |
| Assuntos: | |
| Acesso em linha: | http://link.springer.com/article/10.1186/s13046-017-0596-z |
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