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Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration

Abstract Background Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neurons is an insufficient activation of the Unfolded P...

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Auteurs principaux: Todd McLaughlin, Marek Falkowski, Jae Whan Park, Stephen Keegan, Michael Elliott, Joshua J. Wang, Sarah X. Zhang
Format: Artigo
Langue:Inglês
Publié: BMC 2018-04-01
Collection:Molecular Neurodegeneration
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Accès en ligne:http://link.springer.com/article/10.1186/s13024-018-0250-z
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