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Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration

BACKGROUND: Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neurons is an insufficient activation of the Unfolded Protein R...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: McLaughlin, Todd, Falkowski, Marek, Park, Jae Whan, Keegan, Stephen, Elliott, Michael, Wang, Joshua J., Zhang, Sarah X.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883257/
https://ncbi.nlm.nih.gov/pubmed/29615095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0250-z
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