A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation.

Embryonic stem cells and induced pluripotent stem cells represent potentially important therapeutic agents in regenerative medicine. Complex interlinked transcriptional and signaling networks control the fate of these cells towards maintenance of pluripotency or differentiation. In this study we hav...

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Main Authors: Shen-Hsi Yang, Tuzer Kalkan, Claire Morrisroe, Austin Smith, Andrew D Sharrocks
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2012-01-01
Serija:PLoS Genetics
Online dostop:http://europepmc.org/articles/PMC3521700?pdf=render
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