Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

Abstract Background To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) development. Methods Ten-week-old male C57BL/6 mice were randomized a...

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Detalhes bibliográficos

Principais autores:	Jiansen Lu, Hongbo Zhang, Jianying Pan, Zhiqiang Hu, Liangliang Liu, Yanli Liu, Xiao Yu, Xiaochun Bai, Daozhang Cai, Haiyan Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-05-01
coleção:	Arthritis Research & Therapy
Assuntos:	Osteoarthritis Fargesin Macrophage Mitogen-activated protein kinase pathway Nuclear factor kappa-B pathway
Acesso em linha:	https://doi.org/10.1186/s13075-021-02512-z
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