Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

Abstract Background To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) development. Methods Ten-week-old male C57BL/6 mice were randomized a...

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Bibliografische gegevens

Hoofdauteurs:	Jiansen Lu, Hongbo Zhang, Jianying Pan, Zhiqiang Hu, Liangliang Liu, Yanli Liu, Xiao Yu, Xiaochun Bai, Daozhang Cai, Haiyan Zhang
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2021-05-01
Reeks:	Arthritis Research & Therapy
Onderwerpen:	Osteoarthritis Fargesin Macrophage Mitogen-activated protein kinase pathway Nuclear factor kappa-B pathway
Online toegang:	https://doi.org/10.1186/s13075-021-02512-z
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