Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32

Abstract Emerging evidence has shown an imbalance in M1/M2 macrophage polarization to play an essential role in osteoarthritis (OA) progression. However, the underlying mechanistic basis for this polarization is unknown. RNA sequencing of OA M1-polarized macrophages found highly expressed levels of...

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Detalhes bibliográficos

Principais autores:	Jianbin Yin, Hua Zeng, Kai Fan, Haoyu Xie, Yan Shao, Yuheng Lu, Jinjian Zhu, Zihao Yao, Liangliang Liu, Hongbo Zhang, Bingsheng Luo, Xinjie Wang, Chun Zeng, Xiaochun Bai, Haiyan Zhang, Daozhang Cai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2022-06-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-022-04962-y
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