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RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling

Objectives: To investigate the potential role of Ribosomal protein L35 (RPL35) in regulating chondrocyte catabolic metabolism and to examine whether osteoarthritis (OA) progression can be delayed by overexpressing RPL35 in a mouse compression loading model. Methods: RNA sequencing analysis was perfo...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jinjian Zhu, Liangliang Liu, Rengui Lin, Xiongtian Guo, Jianbin Yin, Haoyu Xie, Yuheng Lu, Zhicheng Zhang, Hongbo Zhang, Zihao Yao, Haiyan Zhang, Xiangjiang Wang, Chun Zeng, Daozhang Cai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-03-01
Schriftenreihe:Journal of Orthopaedic Translation
Schlagworte:
Chondrocyte
Hedgehog pathway
Osteoarthritis
Ribosomal protein L35
Senescence
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2214031X24000056
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