Ultrasound-targeted simvastatin-loaded microbubble destruction promotes OA cartilage repair by modulating the cholesterol efflux pathway mediated by PPARγ in rabbits

Aims: To evaluate the effect of ultrasound-targeted simvastatin-loaded microbubble destruction (UTMD SV ) for alleviation of the progression of osteoarthritis (OA) in rabbits through modulation of the peroxisome proliferator-activated receptor (PPARγ). Methods: In vitro, OA chondrocytes were treated...

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Asıl Yazarlar:	Xinwei Wang, Danbi Wang, Peng Xia, Kai Cheng, Qi Wang, Xiaoju Wang, Qiang Lin, Jiulong Song, Anliang Chen, Xueping Li
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	The British Editorial Society of Bone & Joint Surgery 2021-10-01
Seri Bilgileri:	Bone & Joint Research
Konular:	osteoarthritis simvastatin microbubble cholesterol efflux cartilage repair rabbits chondrocytes aggrecan collagen ii oa chondrocytes high-density lipoprotein (hdl) western blot staining
Online Erişim:	https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.1010.BJR-2021-0162.R3
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