NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks

Modifications of the nucleic acid backbone are essential for the development of oligonucleotide-derived bioactive agents. The NAA-modification represents a novel artificial internucleotide linkage which enables the site-specific introduction of positive charges into the otherwise polyanionic backbon...

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Hlavní autoři:	Boris Schmidtgall, Claudia Höbartner, Christian Ducho
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Beilstein-Institut 2015-01-01
Edice:	Beilstein Journal of Organic Chemistry
Témata:	backbone modifications DNA nucleic acids oligonucleotides stereoselective synthesis zwitterions
On-line přístup:	https://doi.org/10.3762/bjoc.11.8
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