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4′-C-Aminoethoxy modification enhanced nuclease resistance of RNAs and improved thermal stability of RNA duplexes

We designed and synthesized RNAs containing 4′-C-aminoethoxy-2′-O-methyluridine (4′-AEoU), and compared their properties with those containing 4′-C-aminopropyl-2′-O-methyluridine (4′-APU). The RNA duplexes containing 4′-AEoU showed higher melting temperatures than those containing 4′-APU. The 4′-AEo...

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Main Authors: Ryo Tsukimura, Ryohei Kajino, Yujun Zhou, Akash Chandela, Yoshihito Ueno
Format: Artigo
Language:Inglês
Published: Elsevier 2021-01-01
Series:Results in Chemistry
Subjects:
Oligonucleotide
RNA
Small interfering RNA
Aminoethoxy modification
Thermal stability
Nuclease resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715621001363
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