4′-C-Aminoethoxy modification enhanced nuclease resistance of RNAs and improved thermal stability of RNA duplexes

We designed and synthesized RNAs containing 4′-C-aminoethoxy-2′-O-methyluridine (4′-AEoU), and compared their properties with those containing 4′-C-aminopropyl-2′-O-methyluridine (4′-APU). The RNA duplexes containing 4′-AEoU showed higher melting temperatures than those containing 4′-APU. The 4′-AEo...

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Autors principals:	Ryo Tsukimura, Ryohei Kajino, Yujun Zhou, Akash Chandela, Yoshihito Ueno
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-01-01
Col·lecció:	Results in Chemistry
Matèries:	Oligonucleotide RNA Small interfering RNA Aminoethoxy modification Thermal stability Nuclease resistance
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211715621001363
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