Synthesis and Application of 4′-<i>C</i>-[(<i>N</i>-alkyl)aminoethyl]thymidine Analogs for Optimizing Oligonucleotide Properties
Gapmer-type antisense oligonucleotides (ASOs) are an emerging class of therapeutic agents that directly inhibit pathogenic mRNA. In this study, three new 4′-<i>C</i>-substituted thymidine analogs were generated using a synthetic strategy recently established by our group, namely, 4′-<i>C</i>-(<i>N</...
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| Автори: | , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
MDPI AG
2025-01-01
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| Серія: | Molecules |
| Предмети: | |
| Онлайн доступ: | https://www.mdpi.com/1420-3049/30/3/581 |
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