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Structural basis for proton coupled cystine transport by cystinosin

Mutations in CTNS, the lysosomal cystine-proton symporter, cause cystinosis. Here authors report crystal structures of CTNS from Arabidopsis thaliana in complex with cystine, and establish the mode of ligand recognition and mechanism for proton-coupled cystine export from the lysosome.

Wedi'i Gadw mewn:
Prif Awduron: Mark Löbel, Sacha P. Salphati, Kamel El Omari, Armin Wagner, Stephen J. Tucker, Joanne L. Parker, Simon Newstead
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Portfolio 2022-08-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-022-32589-2
Tagiau: Ychwanegu Tag
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