Structural basis for proton coupled cystine transport by cystinosin
Mutations in CTNS, the lysosomal cystine-proton symporter, cause cystinosis. Here authors report crystal structures of CTNS from Arabidopsis thaliana in complex with cystine, and establish the mode of ligand recognition and mechanism for proton-coupled cystine export from the lysosome.
Gardado en:
| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-022-32589-2 |
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