Structural basis for proton coupled cystine transport by cystinosin
Mutations in CTNS, the lysosomal cystine-proton symporter, cause cystinosis. Here authors report crystal structures of CTNS from Arabidopsis thaliana in complex with cystine, and establish the mode of ligand recognition and mechanism for proton-coupled cystine export from the lysosome.
Furkejuvvon:
| Váldodahkkit: | , , , , , , |
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| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
Nature Portfolio
2022-08-01
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| Ráidu: | Nature Communications |
| Liŋkkat: | https://doi.org/10.1038/s41467-022-32589-2 |
| Fáddágilkorat: |
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