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HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response

Abstract The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through neddylation, the covalent attachment of ubiquitin-like protein NEDD8 to CUL1. After substrate degrad...

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Asıl Yazarlar: Shunsuke Nishimura, Hidetaka Kioka, Shan Ding, Hideyuki Hakui, Haruki Shinomiya, Kazuya Tanabe, Tatsuro Hitsumoto, Ken Matsuoka, Hisakazu Kato, Osamu Tsukamoto, Yoshihiro Asano, Seiji Takashima, Radoslav I Enchev, Yasushi Sakata
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Nature 2025-02-01
Seri Bilgileri:EMBO Reports
Konular:
HSC70
SCF Ubiquitin Ligase
COP9 Signalosome
Proteostasis
Stress Response
Online Erişim:https://doi.org/10.1038/s44319-025-00376-x
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