The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity

The COP9 signalosome inhibits the activity of Cullin-RING E3 ubiquitin ligases by removing Nedd8 modifications from their Cullin subunits. Neddylation renders these complexes catalytically active, but deneddylation is also necessary for them to exchange adaptor subunits and avoid auto-ubiquitination...

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Autores principales:	Annabelle Suisse, Miklós Békés, Tony T. Huang, Jessica E. Treisman
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2018-04-01
Colección:	Fly
Materias:	cop9 signalosome cullin wing disc nedd8 ubiquitin ligase
Acceso en línea:	http://dx.doi.org/10.1080/19336934.2018.1429858
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