The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
The COP9 signalosome inhibits the activity of Cullin-RING E3 ubiquitin ligases by removing Nedd8 modifications from their Cullin subunits. Neddylation renders these complexes catalytically active, but deneddylation is also necessary for them to exchange adaptor subunits and avoid auto-ubiquitination...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis Group
2018-04-01
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| Schriftenreihe: | Fly |
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| Online-Zugang: | http://dx.doi.org/10.1080/19336934.2018.1429858 |
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