HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response

Abstract The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through neddylation, the covalent attachment of ubiquitin-like protein NEDD8 to CUL1. After substrate degrad...

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Autors principals:	Shunsuke Nishimura, Hidetaka Kioka, Shan Ding, Hideyuki Hakui, Haruki Shinomiya, Kazuya Tanabe, Tatsuro Hitsumoto, Ken Matsuoka, Hisakazu Kato, Osamu Tsukamoto, Yoshihiro Asano, Seiji Takashima, Radoslav I Enchev, Yasushi Sakata
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2025-02-01
Col·lecció:	EMBO Reports
Matèries:	HSC70 SCF Ubiquitin Ligase COP9 Signalosome Proteostasis Stress Response
Accés en línia:	https://doi.org/10.1038/s44319-025-00376-x
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