Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells

Abstract Background Neurodegenerative conditions that affect the retina are currently the leading cause of incurable blindness in the developed world. Although gene and drug therapies are being developed to slow disease progression in some cases, restorative cell replacement approaches are needed fo...

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Principais autores:	Laura R. Bohrer, Luke A. Wiley, Allison T. Wright, Bradley Hittle, Mallory J. Lang, Louisa M. Affatigato, Kimerly A. Powell, Lorena M. Haefeli, Ian C. Han, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Autologous photoreceptor cell replacement Induced pluripotent stem cell (iPSC) Clinical grade 3D retinal organoids Inherited retinal degeneration Subretinal transplantation
Acesso em linha:	https://doi.org/10.1186/s13287-025-04771-y
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