iPSC-RPE patch restores photoreceptors and regenerates choriocapillaris in a pig retinal degeneration model

Dry age-related macular degeneration (AMD) is a leading cause of untreatable vision loss. In advanced cases, retinal pigment epithelium (RPE) cell loss occurs alongside photoreceptor and choriocapillaris degeneration. We hypothesized that an RPE-patch would mitigate photoreceptor and choriocapillari...

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Prif Awduron:	Rohan Gupta, Irina Bunea, Bruno Alvisio, Francesca Barone, Rishabh Gupta, Dara Baker, Haohua Qian, Elena Daniele, Casey G. Contreary, Jair Montford, Ruchi Sharma, Arvydas Maminishkis, Mandeep S. Singh, Maria Teresa Magone De Quadros Costa, Amir H. Kashani, Juan Amaral, Kapil Bharti
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Clinical investigation 2025-05-01
Cyfres:	JCI Insight
Pynciau:	Ophthalmology Transplantation
Mynediad Ar-lein:	https://doi.org/10.1172/jci.insight.179246
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