iPSC-RPE patch restores photoreceptors and regenerates choriocapillaris in a pig retinal degeneration model

Dry age-related macular degeneration (AMD) is a leading cause of untreatable vision loss. In advanced cases, retinal pigment epithelium (RPE) cell loss occurs alongside photoreceptor and choriocapillaris degeneration. We hypothesized that an RPE-patch would mitigate photoreceptor and choriocapillari...

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Detalhes bibliográficos

Principais autores:	Rohan Gupta, Irina Bunea, Bruno Alvisio, Francesca Barone, Rishabh Gupta, Dara Baker, Haohua Qian, Elena Daniele, Casey G. Contreary, Jair Montford, Ruchi Sharma, Arvydas Maminishkis, Mandeep S. Singh, Maria Teresa Magone De Quadros Costa, Amir H. Kashani, Juan Amaral, Kapil Bharti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical investigation 2025-05-01
coleção:	JCI Insight
Assuntos:	Ophthalmology Transplantation
Acesso em linha:	https://doi.org/10.1172/jci.insight.179246
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