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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

<p>Abstract</p> <p>Background</p> <p>Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously reported that loss of LRRK2 causes impairment of protein...

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Principais autores: Tong Youren, Giaime Emilie, Yamaguchi Hiroo, Ichimura Takaharu, Liu Yumin, Si Huiqing, Cai Huaibin, Bonventre Joseph V, Shen Jie
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-01-01
Serier:Molecular Neurodegeneration
Fag:
LRRK2
Parkinson's disease
knockout
LC3
p62
lysosomal proteins
cathepsins
lipofuscin
Online adgang:http://www.molecularneurodegeneration.com/content/7/1/2
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