Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Abstract Background Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously reported that loss of LRRK2 causes impairment of protein...

Ful tanımlama

Kaydedildi:

Detaylı Bibliyografya
Asıl Yazarlar:	Tong Youren, Giaime Emilie, Yamaguchi Hiroo, Ichimura Takaharu, Liu Yumin, Si Huiqing, Cai Huaibin, Bonventre Joseph V, Shen Jie
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	BMC 2012-01-01
Seri Bilgileri:	Molecular Neurodegeneration
Konular:	LRRK2 Parkinson's disease knockout LC3 p62 lysosomal proteins cathepsins lipofuscin
Online Erişim:	http://www.molecularneurodegeneration.com/content/7/1/2
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Benzer Materyaller