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DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with tumor aggressiveness and outcome. What signals and...

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Main Authors: Samantha VH Bayer, Whitney R Grither, Audrey Brenot, Priscilla Y Hwang, Craig E Barcus, Melanie Ernst, Patrick Pence, Christopher Walter, Amit Pathak, Gregory D Longmore
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
mechanotransduction
collagen
DDR2
Integrins
metastasis
Online Access:https://elifesciences.org/articles/45508
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