DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with tumor aggressiveness and outcome. What signals and...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Samantha VH Bayer, Whitney R Grither, Audrey Brenot, Priscilla Y Hwang, Craig E Barcus, Melanie Ernst, Patrick Pence, Christopher Walter, Amit Pathak, Gregory D Longmore
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2019-05-01
Schriftenreihe:	eLife
Schlagworte:	mechanotransduction collagen DDR2 Integrins metastasis
Online-Zugang:	https://elifesciences.org/articles/45508
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!