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DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with tumor aggressiveness and outcome. What signals and...

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Kaydedildi:
Asıl Yazarlar: Samantha VH Bayer, Whitney R Grither, Audrey Brenot, Priscilla Y Hwang, Craig E Barcus, Melanie Ernst, Patrick Pence, Christopher Walter, Amit Pathak, Gregory D Longmore
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications Ltd 2019-05-01
Seri Bilgileri:eLife
Konular:
mechanotransduction
collagen
DDR2
Integrins
metastasis
Online Erişim:https://elifesciences.org/articles/45508
Etiketler: Etiketle
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