Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer
Base editing technology is being increasingly applied in genome engineering, but the current strategy for designing guide RNAs (gRNAs) relies substantially on empirical experience rather than a dependable and efficient in silico design. Furthermore, the pleiotropic effect of base editing on disease...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2023-12-01
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| Serie: | Genomics, Proteomics & Bioinformatics |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S1672022922000821 |
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