Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer

Base editing technology is being increasingly applied in genome engineering, but the current strategy for designing guide RNAs (gRNAs) relies substantially on empirical experience rather than a dependable and efficient in silico design. Furthermore, the pleiotropic effect of base editing on disease...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Gongchen Zhang, Chenyu Zhu, Xiaohan Chen, Jifang Yan, Dongyu Xue, Zixuan Wei, Guohui Chuai, Qi Liu
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Oxford University Press 2023-12-01
Σειρά:	Genomics, Proteomics & Bioinformatics
Θέματα:	Gene editing Base editing Pleiotropy CRISPR/Cas9 gRNA design
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S1672022922000821
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