Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer

Base editing technology is being increasingly applied in genome engineering, but the current strategy for designing guide RNAs (gRNAs) relies substantially on empirical experience rather than a dependable and efficient in silico design. Furthermore, the pleiotropic effect of base editing on disease...

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Hlavní autoři:	Gongchen Zhang, Chenyu Zhu, Xiaohan Chen, Jifang Yan, Dongyu Xue, Zixuan Wei, Guohui Chuai, Qi Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2023-12-01
Edice:	Genomics, Proteomics & Bioinformatics
Témata:	Gene editing Base editing Pleiotropy CRISPR/Cas9 gRNA design
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1672022922000821
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