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Depletion of Demethylase KDM6 Enhances Early Neuroectoderm Commitment of Human PSCs

Epigenetic modifications play a crucial role in neurogenesis, learning, and memory, but the study of their role in early neuroectoderm commitment from pluripotent inner cell mass is relatively lacking. Here we utilized the system of directed neuroectoderm differentiation from human embryonic stem ce...

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Principais autores: Yajing Meng, Tianzhe Zhang, Ran Zheng, Song Ding, Jie Yang, Ran Liu, Yingan Jiang, Wei Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-09-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
KDM6
neuroectoderm differentiation
human embryonic stem cell
GSK-J1
KDM6A
KDM6B
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2021.702462/full
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