Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5
Abstract Background Lysine demethylase 5 (KDM5) family proteins are transcriptional regulators best known for demethylating the promoter-proximal histone mark H3K4me3. KDM5-mediated regulation of gene expression is crucial in the brain, with pathogenic variants in human KDM5 genes leading to intelle...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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BMC
2025-12-01
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| Schriftenreihe: | Epigenetics & Chromatin |
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| Online-Zugang: | https://doi.org/10.1186/s13072-025-00644-z |
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