Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots

The somatic hypermutation (SHM) of Immunoglobulin (Ig) genes is a key process during antibody affinity maturation in B cells. The mutagenic enzyme activation induced deaminase (AID) is required for SHM and has a preference for WRC hotspots in DNA. Error-prone repair mechanisms acting downstream of A...

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Autori principali:	Artem Krantsevich, Catherine Tang, Thomas MacCarthy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2021-02-01
Serie:	Frontiers in Immunology
Soggetti:	B cell receptor activation-induced deaminase computational immunology immunoglobulin heavy chain somatic hypermutation overlapping hotspots
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.618409/full
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