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Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots

The somatic hypermutation (SHM) of Immunoglobulin (Ig) genes is a key process during antibody affinity maturation in B cells. The mutagenic enzyme activation induced deaminase (AID) is required for SHM and has a preference for WRC hotspots in DNA. Error-prone repair mechanisms acting downstream of A...

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Principais autores: Artem Krantsevich, Catherine Tang, Thomas MacCarthy
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-02-01
coleção:Frontiers in Immunology
Assuntos:
B cell receptor
activation-induced deaminase
computational immunology
immunoglobulin heavy chain
somatic hypermutation
overlapping hotspots
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2020.618409/full
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