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Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity

Abstract Background Spaceflight and microgravity environments have been shown to cause significant health impairments, including bone loss, immune dysfunction, and hematopoietic disorders. Hematopoietic stem cells (HSCs), as progenitors of the hematopoietic system, are critical for the continuous re...

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Principais autores: Xiru Liu, Hao Zhang, Jinxiao Yan, Penghui Ye, Yanran Wang, Nu Zhang, Zhenhao Tian, Bin Liu, Hui Yang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-03-01
Serier:Stem Cell Research & Therapy
Fag:
Microgravity
Hindlimb unloading
HSCs
Proliferation
Differentiation
Online adgang:https://doi.org/10.1186/s13287-025-04213-9
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