Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity

Abstract Background Spaceflight and microgravity environments have been shown to cause significant health impairments, including bone loss, immune dysfunction, and hematopoietic disorders. Hematopoietic stem cells (HSCs), as progenitors of the hematopoietic system, are critical for the continuous re...

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Hlavní autoři:	Xiru Liu, Hao Zhang, Jinxiao Yan, Penghui Ye, Yanran Wang, Nu Zhang, Zhenhao Tian, Bin Liu, Hui Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-03-01
Edice:	Stem Cell Research & Therapy
Témata:	Microgravity Hindlimb unloading HSCs Proliferation Differentiation
On-line přístup:	https://doi.org/10.1186/s13287-025-04213-9
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