Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages

The apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) is an adaptor molecule that mediates inflammatory and apoptotic signals. Legionella pneumophila (L. pneumophila) is an intracellular bacterium and the causative agent of Legionnaire’s pneumonia. L. pneumophila...

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Principais autores:	Amal O Amer, Dalia H.A. Abdelaziz, Mikhail A Gavrilin, Anwari eAkhter, Kyle eCaution, Sheetal eKotrange, Arwa eAbu Khweek, Basant A. Abdulrahman, Zeinab A. Hassan, Fathia Z. El-Sharkawi, Simranjit S. Bedi, Katherine eLadner, Mahmoud eMostafa, Andrea eDoseff, Elba M Gonzalez-Mejia, Dennis eGuttridge, Thirumala-Devi eKanneganti, Clay B. Marsh, Mark D. Wewers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2011-02-01
coleção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	Legionella pneumophila Inflammasome caspase-1 ASC
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00018/full
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