Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer’s Mouse Model With Tau Pathology

Neurofibrillary tangles (NFTs) are a major pathologic hallmark of Alzheimer’s disease (AD). Several studies have shown that amyloid β oligomers (Aβo) and tau oligomers mediate their toxicity, in part, via binding to cellular prion protein (PrPC) and that some anti-PrP antibodies can block this inter...

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Bibliografische Detailangaben

Hauptverfasser:	Allal Boutajangout, Wei Zhang, Justin Kim, Wed Ali Abdali, Frances Prelli, Thomas Wisniewski
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-02-01
Schriftenreihe:	Frontiers in Aging Neuroscience
Schlagworte:	Alzheimer’s disease immunotherapy prion tau related pathology passive immunization transgenic mice
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.640677/full
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