Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer’s Mouse Model With Tau Pathology

Neurofibrillary tangles (NFTs) are a major pathologic hallmark of Alzheimer’s disease (AD). Several studies have shown that amyloid β oligomers (Aβo) and tau oligomers mediate their toxicity, in part, via binding to cellular prion protein (PrPC) and that some anti-PrP antibodies can block this inter...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Allal Boutajangout, Wei Zhang, Justin Kim, Wed Ali Abdali, Frances Prelli, Thomas Wisniewski
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2021-02-01
Serie:	Frontiers in Aging Neuroscience
Soggetti:	Alzheimer’s disease immunotherapy prion tau related pathology passive immunization transgenic mice
Accesso online:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.640677/full
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!