Cell type-specific inference from bulk RNA-sequencing data by integrating single-cell reference profiles via EPIC-unmix

Abstract Cell type-specific analysis is crucial for uncovering biological insights hidden in bulk tissue data, yet single-cell or single-nuclei approaches are often cost-prohibitive for large samples. We introduce EPIC-unmix, a novel two-step empirical Bayesian method combining reference single-cell...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Chenwei Tang, Quan Sun, Xinyue Zeng, Gang Li, Xiaoyu Yang, Fei Liu, Jinying Zhao, Yin Shen, Boxiang Liu, Jia Wen, Yun Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Genome Biology
Online-Zugang:	https://doi.org/10.1186/s13059-025-03847-5
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!