Cell type-specific inference from bulk RNA-sequencing data by integrating single-cell reference profiles via EPIC-unmix
Abstract Cell type-specific analysis is crucial for uncovering biological insights hidden in bulk tissue data, yet single-cell or single-nuclei approaches are often cost-prohibitive for large samples. We introduce EPIC-unmix, a novel two-step empirical Bayesian method combining reference single-cell...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2025-11-01
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| coleção: | Genome Biology |
| Acesso em linha: | https://doi.org/10.1186/s13059-025-03847-5 |
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