Cell type-specific inference from bulk RNA-sequencing data by integrating single-cell reference profiles via EPIC-unmix

Abstract Cell type-specific analysis is crucial for uncovering biological insights hidden in bulk tissue data, yet single-cell or single-nuclei approaches are often cost-prohibitive for large samples. We introduce EPIC-unmix, a novel two-step empirical Bayesian method combining reference single-cell...

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Hlavní autoři:	Chenwei Tang, Quan Sun, Xinyue Zeng, Gang Li, Xiaoyu Yang, Fei Liu, Jinying Zhao, Yin Shen, Boxiang Liu, Jia Wen, Yun Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-11-01
Edice:	Genome Biology
On-line přístup:	https://doi.org/10.1186/s13059-025-03847-5
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